Stem Cells Handbook

Stem Cells Handbook

Language: English

Pages: 534

ISBN: 146147695X

Format: PDF / Kindle (mobi) / ePub

This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells. The text covers basic knowledge of stem cell biology, stem cell ethics, development of techniques for applying stem cell therapy, the technology of obtaining appropriate cells for transplantation as well as the role of stem cells in cancer and how therapy may be directed to cancer stem cells. This new volume is essential reading for all scientists currently in the field or allied research areas, and those for those graduate students who envision a career in stem cells.



















continuous supply of cells from Sox9 progenitors. Iverson et al. [10] have sought to quantify the dynamics of mouse liver turnover by lineage labeling following activation of an albumin/Cre transgene, calculating that 0.076 % of hepatocytes had differentiated from albumin-naïve cells over a 4-day period. If these new cells have not arisen from biliary cells or periportal stem cells, are there any other cellular sources? Perhaps they could have arisen from small hepatocyte-like progenitors (SHPCs)

potential and capacity of hepatic progenitors to restore functional liver mass. In addition to the role of stem cells in liver regeneration, we will also review the contribution of these cells to the development of hepatocellular carcinoma. Finally we will discuss the future direction of the field of hepatic stem/progenitor cells and the potential therapeutic use of these cells in liver disease. Introduction The concept of bipotent hepatic progenitor cells residing in the cholangioles, the

essential to consider. Epiblast Stem Cells (EpiSC) Mouse ES cells derived from the EPI lineage of the blastocyst were the primary in vitro model of pluripotency for almost 25 years. Recently, however, pluripotent cell lines have been derived from early postimplantation stage mouse embryos, namely the EpiSC [18, 19]. Even though both ES cells and EpiSCs are pluripotent (Fig. 5), they differ in several respects: EpiSC cannot colonize the ICM of a blastocyst; consequently, the ability of these

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