Drawing the Map of Life: Inside the Human Genome Project (A Merloyd Lawrence Book)
Victor K. McElheny
Language: English
Pages: 400
ISBN: 0465028950
Format: PDF / Kindle (mobi) / ePub
17, 2008; “National Institutes of Health awards more than $54 million to Kaiser Permanente to conduct health research,” Reuters, October 12, 2009; “Kaiser Permanente, UCSF Land $25M Grant for Genotyping Effort,” GenomeWeb.com, October 12, 2009. Website: For information about the study, see www.dor.kaiser.org/studies/rpgeh. Newspapers: Carl T. Hall, “Kaiser Starts Major Study of Members’ Health; HMO Will Survey Health and Habits over 50 Years,” San Francisco Chronicle, February 15, 2007, B3;
genome, 170, 185, 225 Domenici, Pete, 58, 93–94, 98 Donis-Keller, Helen, 50, 69, 107 Donnelly, Peter, 207, 214, 214–215 Doolittle, Russell, 68, 75 Double Helix, The (Watson), 76 Double Twist corporation, 160 Double-helix model, 4, 16, 181 Down syndrome, 21, 228 Drazen, Jeffrey, 225 Dreyer, William, 22 Drosophila (fruit fly), xi, 71, 72, 92, 123, 146, 155–156, 157, 170 Drugs antiretrovirals, 12 Avastin, 234 biotechnology, 203 “blockbuster,” 229, 253 blood-thinning, 63, 244–245
further dramatic declines. Undaunted, however, Celera agreed on March 20 to merge with Paracel, a company in Pasadena, California, that specialized in genome analysis. Venter was still intent on his goal of building Celera into an information company like Bloomberg.53 A Script for Life: “The Real Fun Starts Now” In June 2000, as the public announcement of success in drafting a human genome drew near, many attempted to describe what the world would be like when it had a preliminary blueprint of
sequencing methods. Very soon, the SNPs had company as badges of genetic variation. Little-suspected, large new classes of genetic differences, within and between species, had to be considered alongside those that previously preoccupied genomic researchers. The catchall names for the numerous mutations included “rearrangements,” “structural variations,” or “copy-number changes.” As early as 2003, it was evident that the evolution from primates to humans had brought changes not only within known
Death Row. Since 1989, the U.S.-based Innocence Project has calculated, DNA evidence has cleared more than 220 prisoners in thirty-three American states. The first use of such DNA forensics was in proving that a boy from Ghana really was the son of a woman in England who claimed she was his mother. Not only did DNA fingerprinting settle paternity cases, but, as in the destruction of the World Trade Towers, it identified people whose remains could be determined no other way.15 Because DNA